Accordingly, what is the difference between the binding of Isaac and rebirth?
The original Binding of Isaac has nothing exclusive, so I think you can start with Rebirth, which is a remake of the original one. The newest version has more characters, more items, more achievements and more challenges, and quite everything that was in the older game is present in Rebirth.
Also Know, do you need binding of Isaac Rebirth afterbirth? Yes. It's DLC, not a stand-alone game.
Also asked, which is better binding of Isaac rebirth or afterbirth?
Rebirth is the remake of the original binding of Isaac. Afterbirth is the dlc for rebirth. I highly recommend getting afterbirth if you are planning on getting rebirth as it just adds a crap ton to the game. Rebirth is a sequel to the original BoI, Afterbirth (and Afterbirth+) is a dlc for Rebirth.
What is the best version of binding of Isaac?
Afterbirth+